We start by loading in the FASTA for the Serotonin Receptor 6 (can be found here: https://www.ncbi.nlm.nih.gov/protein/P50406.1?report=fasta).

The loaded sequence then gets forwarded to the OmegaFold-Node where its 3D structure gets predicted. To get a preview of the structure, it is sent to the "Protein Structure Viewer"-Node.

To do the docking, we pipe the predicted structure into the DiffDock-Node. The second input for DiffDock is the chemical structure of the serotonin molecule which we get from the "Smiles To Structure"-Node. This node is provided with a SMILES string of the required molecule.

DiffDock outputs the spatial information for the docked molecule. To see the molecule in its docked position with the folded receptor, we combine the structures with the "Add SDF to PDB"-Node.

The combined structure can then be viewed with another "Protein Structure Viewer". To get an even better view, click the "Open in MolStar" button.